A comparative study of the effectiveness and safety of using preparations of colloidal bismuth tripotassium dicitrate in patients with gastric and duodenal ulcers

Prohibited during pregnancy

Prohibited during breastfeeding

Allowed for children

Allowed for older people

Has limitations for liver problems

Prohibited for kidney problems

De-Nol belongs to the drugs that affect the functioning of the gastrointestinal tract. Produced in the Netherlands. The drug has no synonyms, but there are many analogues according to the mechanism of action that can replace De-Nol if it is intolerant.

A medicine based on bismuth tripotassium dicitrate is produced in the form of round, biconvex tablets for internal use. It has gastroprotective, antibacterial and anti-inflammatory effects.

General information about the drug

Indications for its use are disorders of the gastrointestinal tract:

• ulcerative lesions of the stomach and duodenum;
• erosive gastritis;
• ulcerative colitis of nonspecific form;
• complex eradication of Helicobacter pylori;
• disorders of the gastrointestinal tract while taking any NSAIDs.

It is not recommended for use during pregnancy and breastfeeding due to the presence of heavy metal salts in its composition that can penetrate the placental and blood-brain barriers. In pediatric practice, it is allowed only from 14 years of age. Earlier intake is possible according to an individual dosage regimen and exclusively as complex anti-Helicobacter therapy.

Prices for the drug and its main analogues, average in Russia

The pharmacy chain offers a sufficient number of De-Nol analogues.
These are both domestic and foreign drugs. They all belong to the same group of drugs, but have minor differences in the mechanism of action and price. The cost of the most common analogues in Russian pharmacies:

Is it possible to take Ulcavis and De-Nol at the same time?

It is strictly forbidden to combine these medications. Both drugs have the same composition and active substance, therefore they are considered analogues. The simultaneous use of Ulcavis and De-Nol can provoke an overdose. If the amount of bismuth in the body is too high, kidney dysfunction and intoxication occur.

To select the appropriate medication, you must consult a specialist - a gastroenterologist. Taking medications without a doctor's prescription is strictly prohibited. This approach will not give the desired effect, but will only worsen the patient’s condition. Before prescribing any medications, the disease must be diagnosed.

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Cheaper similar products

Due to the fairly high cost of the main product, patients sometimes have to look for cheaper analogues of De-Nol. However, these drugs cannot be called less effective. Some of them are quite capable of competing with expensive products.

Venter

Produced in Slovenia. The international nonproprietary name is Sucralfate, according to the active component of the drug. The drug does not have a systemic effect. The active substance accumulates in the stomach during treatment, interacting with the protein structures of the necrotic ulcer. In this way, a quick cure for gastric ulcers is achieved. 10-15% of sucralfate is excreted unchanged by the kidneys.

Venter

It is rarely used as an independent remedy in gastroenterology, mainly as part of complex therapy. The medication has virtually no contraindications, with the exception of individual intolerance to the active substance.

Vikalin

A combined drug that is used for ulcerative colitis and gastroesophageal reflux disease. The product contains bismuth nitrate, magnesium carbonate, sodium bicarbonate, calamus rhizome powder, kellin, rutin.

Action of Vikalin

It has classic astringent, enveloping and antacid effects. When applied, the tongue may turn black. The main feature of the medication is the incompatibility of the main substance with fermented milk products, which should be excluded during treatment.

Omeprazole

The drug based on the substance of the same name, omeprazole, is an H2 receptor antagonist. Country of origin: India. Available in the form of capsules consisting of two halves, white and pink. The capsule is coated with an enteric-soluble coating.

The product blocks the operation of the ion pump and minimizes the release of HCl in the stomach. Thanks to this, the factor that irritates the damaged epigastric mucosa is eliminated. Take 1 capsule 2 times a day for 2-4 weeks. It has virtually no contraindications. The manufacturer has no information about the occurrence of overdoses.

Lancerol

Production facilities are located in Ukraine. Lansoprazole capsules are white and gelatin-coated. Lancerol affects the release of hydrochloric acid. Main indications for use:

• stomach ulcer;
• erosive gastritis;
• stress ulcers.

Erosive gastritis

The drug has a small clinical base for use in different categories of patients, so its use in children and pregnant women is highly not recommended.

Domestic substitutes

All De-Nol analogues are highly effective and have similar indications for use. In this case, the choice of drug must be agreed with the attending physician.

Vikair

This is a complex medication with a multi-faceted effect:

• antacid;
• antiseptic;
• antispasmodic;
• laxative.

The drug is available in pink tablets. It contains a combination of active ingredients - extracts from calamus root and bismuth nitrate. It has the ability to influence the nerve endings of the gastrointestinal tract, while improving digestion and metabolism.

Prescribed orally, one tablet three times a day after meals. The course of treatment lasts at least 3 months. Vikair is indicated for diseases of the digestive system of various etiologies, such as;

• stomach ulcer and duodenitis;
• bloating;
• dyspeptic disorders;
• gastritis.

It should be used with caution with other drugs containing bismuth, since in this case its concentration in the blood increases and the risk of developing encephalopathy increases. A peculiarity of the use of Vikair is the appearance of black stool and increased frequency of stools after taking it. Pregnancy and lactation are a direct contraindication for use.

Novobismol

The medication belongs to the group of intestinal antiseptic and astringent agents. Release form: tablets. The main active component is bismuth tripotassium dicitrate, which protects the mucous membrane of the digestive tract from destruction, maintaining its integrity. It has a pronounced bactericidal and anti-Helicobacter effect.

Features of the drug use

In the presence of erosions and ulcers, it forms films on their surface. In pediatric practice, it is indicated for children from 8 years of age. Prescribed 2 tablets twice a day. Contraindicated during pregnancy and breastfeeding. Compatible with most medications.

Ranitidine

The most famous medication from the group of H2-histamine receptor blockers. The mechanism of its action is based on the regulation of the production of hydrochloric acid in the stomach, as a result of which favorable conditions are created for the healing of ulcers and erosions. It is available not only in tablet form, but also in injection form. The main active ingredient is ranitidine hydrochloride. Taken in an average daily dose of 300 mg - 1 tablet 2 times a day.

Properties of Ranitidine

Injections are prescribed in extremely severe conditions. Main indications: peptic ulcer and erosive gastritis. A contraindication to the use of Ranitidine is cancer.

Ventrisol

The main constituent substance is bismuth dipotassium dicitrate. Release form: round white tablets, 120 mg of active ingredient. It has a complex antispasmodic and antacid effect on the mucous membrane of the stomach and intestines.

The components of Ventrisol interact with surface proteins, forming insoluble complexes that are highly resistant to mechanical damage.

A group of ulcerative lesions of the gastrointestinal tract is the main indication. Contraindicated in the first trimester of pregnancy and in children under 4 years of age. Before prescribing, a thorough examination of the urinary system is necessary.

Escape

Belongs to the pharmacological group of antiulcer drugs. It has an antiseptic, anti-inflammatory and astringent effect. The main effect of the medication is aimed at:

• destruction of the bacterium Helicobacter pylori;
• providing conditions in which it is difficult for a microorganism to develop.

Active ingredient: Escape

A special feature of Escape is the presence in its composition of povidone, an enterosorbent that can absorb and remove toxins. The product is produced in the Russian Federation by the pharmaceutical concern Optisipharm. Widely used in therapeutic and gastroenterological practice.

Reviews about the drug "De-Nol"

Glushko Svetlana Mikhailovna (gastroenterologist)

I always prescribe De-Nol to patients with gastritis and ulcers. You cannot take it on your own. Experts prescribe the drug only after an accurately confirmed diagnosis. Bismuth medicines promote healing of ulcers. Therapy must be combined with a strict diet. The cost of the drug is quite high, so sometimes it is necessary to replace it with an affordable generic. No significant differences were noticed between “De-Nol” and “Ulkavis”.

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Diana, 28 years old

The doctor discovered I have gastritis. The cause of the disease was Helicobacter pylori infection. The doctor said that gastritis can only be cured by eliminating the reason why this disease began to develop and prescribed De-Nol. I took the pills for 3 months. For more than a year, the symptoms of gastritis did not bother me. Recently, due to a nervous background, the disease worsened. This time "Ulkavis" was appointed. This drug perfectly relieves the symptoms of gastritis.

Foreign analogues of De-Nol

Drugs produced in our country compete freely on the market with foreign drugs. However, it is worth considering that their mechanism of action is the same. Foreign medicines are usually more expensive.

Omez

This is a widely used Indian drug in the pharmacy chain. Available in the form of capsules with 20 mg of the active substance omeprazole. Refers to H2 receptor blockers. Prescribed as a capsule twice a day for:

• functional gastrointestinal disorders;
• peptic ulcer;
• Solinger-Elison syndrome;
• reflux disease.

Description of Omez

The main substance inhibits the pump in the stomach, thereby reducing acidity. The effect lasts for a long time, about 24 hours.

Phosphalugel

The only gastroprotective drug available in the form of a gel for internal use. Thanks to this, Phosphalugel is considered unique of its kind. Country of origin: the Netherlands.

The gel is dosed in sachets. One package contains:

• purified water;
• sorbifer;
• aluminium oxide;
• pectin;
• calcium sulfate;
• orange flavoring.

This composition provides an effective antacid effect, reducing the manifestation of gastroenterological pathology. Unlike other drugs, Phosphalugel is allowed to be taken throughout pregnancy and breastfeeding, as well as for children over 5 years of age.

Ulcavis

A special feature of the drug is the ability to accumulate epidermal growth factor, thanks to which ulcers and erosions heal much faster. Ulcavis is not absorbed in the intestines. Only a small part of it that enters the bloodstream is excreted by the kidneys. Contraindicated in severe somatic conditions, as well as during pregnancy, breastfeeding and children under 4 years of age.

Vis-Nol

Unlike the standard antiulcer effect, it has the ability to increase the production of specific prostaglandins and mucin. As a result, pathological symptoms in the primary lesion area are reduced. Most of the active substance does not undergo transformation in the body and is excreted in feces. Indications are standard in gastroenterological practice:

• stomach ulcer;
• gastritis;
• reflux esophagitis.

Reflux esophagitis

Treatment with Vis-Nol takes up to 2 months. It is also used in a comprehensive Helicobacter pylori eradication scheme. The medicine is produced in Ukraine.

Gastro-Norm

Produced in tablet form. Prescribed 1 tablet three times a day, both in monotherapy and in combination with other anti-Helicobacter and gastroprotective drugs. Prohibited for children under 5 years of age, pregnant and lactating women.

It is not recommended to take the medication for a long time, as the risk of developing encephalopathy increases.