Possibilities of using rectal suppositories with NSAIDs

Updated December 29, 2020
Hello, dear readers of the KtoNaNovenkogo.ru blog. When treating diseases, doctors prescribe medications of various pharmacological forms.

Often, an excellent therapeutic effect can be achieved with the help of suppositories.

The suppositories are administered rectally - the active components of the product act locally on the lesion, minimizing the risk of developing serious complications.

However, difficulties often arise with the use of rectal suppositories. How is it rectal? How to administer suppositories correctly? Are there any contraindications? First things first!

When is it preferable to use rectal suppositories?

Medicines in the form of suppositories that are inserted into the rectum are traditionally used in the following cases:

1. the patient is unconscious. This method of treatment is becoming one of the possible ones.
2. The patient has been diagnosed with a mental disorder. It can be difficult to persuade such patients to take medicine by mouth;
3. An infant or newborn will need to be treated. The child is capricious and clenches his jaw tightly. It is impossible to give medicine in the form of tablets, capsules, syrup - suppositories help out. In this case, it is also important to measure temperature rectally;
4. the pathology is localized in the anal area. After the suppositories dissolve, the active components begin to act directly on the lesion.

Questions

1. Why do your drugs look like sugar? Maybe it's a placebo?
2. Tell me, what is the difference between Vet 1.1 and for example Vet 3?
3. What is the mechanism of action of your drugs?
4. Why do your drugs work on many diseases? What is this, a panacea?
5. How to take your medications correctly?
6. What are the storage conditions for VETOmov and BIOSEPTIN?
7. Where can I buy your drugs?

Answers

Why do your drugs look like sugar? Maybe it's a placebo?

Answer:

The placebo effect (pacifier) ​​is based on self-hypnosis, when a person is convinced that this drug will definitely help, and... sometimes it helps.

VETOM series preparations are spores of bacteria Bacillus subtilis strain VKPM B 7048, Bacillus licheniformis strain VKPM B 7038, Bacillus subtilis strain VKPM B 7092 and if you sprinkle them in a bunch, then you simply won’t see a million spores and they will scatter in the air. To somehow hold them, you need a surface to which they will attach. The ideal surface is powdered sugar, as it is a natural preservative and prevents spores from awakening ahead of time. When they enter a favorable environment, the spores awaken and the bacteria begin active life.

One gram of powder from the VETOM series contains at least one million spores or 106 spores/gram.

Tell me, what is the difference between Vet 1.1 and for example Vet 3?

Answer:

Vetom 1.1 and Vetom 3 are used for the correction of immunodeficiency states not formed due to HIV infection, the drug restores and preserves the intestinal microcenosis during dysbiosis, also after a course of antibiotic treatment, is suitable as an additional remedy for the treatment of herpes (genital, shingles, etc. ), encephalitis, influenza and acute respiratory viral infections, cytomegalovirus infections.

It is used in patients with malignant tumors for prophylactic purposes, to reduce the toxic effect of chemotherapy, radiation therapy, as a general tonic and detoxifying agent that restores the body's antitumor resistance. Normalizes the level of bilirubin, transaminases and other enzymes in the blood, increases appetite and general body tone in viral hepatitis A, B and C. Can be used in the treatment of hairy cell leukemia, chronic myelogenous leukemia, multiple myeloma, kidney cancer, AIDS-related Kaposi's sarcoma, fungiform mycosis, reticulosarcoma, cancer of the rectum, lung, breast, and other types of cancer.

It is used as an additional remedy for infectious diarrhea, treatment of urethritis, gastric and duodenal ulcers, respiratory tract diseases, allergies, radiation sickness, myasthenia gravis, multiple sclerosis, barrel disease. After taking the drug, the degree and speed of alcohol intoxication when drinking alcoholic beverages is significantly reduced. Vetom 2 has immunostimulating, bactericidal, fungicidal and antichlamdia activity, and also the ability to stimulate the functioning of the large intestine. Normalizes the functioning of the large intestine. Used to correct, restore and preserve intestinal microcenosis during dysbacteriosis, as well as after a course of antibiotic treatment.

The drug eliminates putrefactive processes in the large intestine, and therefore it is prescribed in the presence of bad breath and sweating. The drug is used as a preventive and additional treatment for liver cirrhosis, chronic hepatitis, colitis, gastroenterocolitis, constipation, dysentery, gastro-ulcerative diseases

The drug normalizes water-salt metabolism in the body, and therefore can be used as a preventive and additional treatment for kidney stone disease. The drug suppresses the growth and development of chlamydia. Vetom 4 is used for the correction, restoration and preservation of microcenosis in the small part of the gastrointestinal tract during dysbacteriosis, also after a course of antibiotic treatment, as a preventive and additional treatment for liver cirrhosis, chronic hepatitis, colitis, gastroenterocolitis, constipation, dysentery, gastro-ulcerative diseases, polyps, chronic enteritis, enterocolitis; to normalize lipid, protein, and carbohydrate metabolism in the body; to suppress the growth and development of chlamydia.

What is the mechanism of action of your drugs?

Answer:

To answer this question, you need to read a dozen or two dissertations written on the topic “Research of Vetom drugs” and you still won’t find a complete answer in them. The mechanism of interaction between microorganisms is so complex.

Here is a brief description of what we found out.

In the process of life, microorganisms produce enzymes that they need to decompose protein compounds into simple components, which they feed on. (the human body also produces enzymes to feed itself). But the human body does not produce all types of enzymes, so it uses enzymes produced by microbes.

To fight other types of bacteria for living space, bacteria secrete natural antibiotics that suppress the development of other bacteria (this is their property and is the main active principle in VETOM preparations)

The VETOM series preparations use specially selected and studied strains that produce natural antibiotics that are active specifically against pathogenic microflora.

In addition, bacteria produce vitamins, amino acids and many other useful things for the human body.

When taking VETOM medications, the number of Bacillus subtilis bacteria is no more than one percent of the total amount of normal intestinal microflora. And since the bacteria Bacillus subtilis does not belong to the normal microflora, after stopping the drug, after a maximum of 30 days, they are completely eliminated from the body.

You can read a more complete description in “Strain Properties” on the “Reference Materials” tab.

Why do your drugs work on many diseases? What is this, a panacea?

Answer:

A panacea is a mythical medicine that cures all diseases.

Of course, our drugs are not a panacea, but when, with the help of VETOM drugs, the body gets rid of pathogenic microbes that poison the body with their toxins, the vital forces of the body are released to fight the disease and the body itself begins to actively recover. It should be noted that, unlike antibiotics, the normal microflora is not killed, and a milder and more natural effect does not lead to a stressful state, which also affects the effectiveness of treatment.

In addition, only in the drug Vetom1.1 the bacterium Bacillus subtilis strain VKPM B 7092 is modified with the plasmid rBMV 105, capable of producing human interferon 2-alpha-leukocyte. This interferon enters the body not through intramuscular injection, but is naturally absorbed through the intestinal walls, which allows the body to accept it without rejection and an immune response. (the body decides for itself whether it needs interferon or not) Therefore, a relatively small amount of interferon has a greater therapeutic effect.

You can read a more complete description in “Strain Properties” on the “Reference Materials” tab.

How to take your medications correctly?

Answer:

Currently, there are drugs on the market in various formulations: powders, capsules, suppositories, liquids, gels. Depending on the type of disease, location, severity of the disease, etc. a person must select the desired dosage form, frequency and duration of use.

When selecting the dosage and frequency of administration, it is necessary to keep in mind that the therapeutic effect directly depends not on the amount of the drug taken at a time, but on the frequency of use - the more often, the higher the therapeutic effect. One dose should contain at least 5 million microorganisms. That is, at least 5 grams of powder (about a teaspoon). An overdose has no negative consequences.

For preventive purposes: Frequency - at least 5-7 doses per day. The duration of the course is 10 days.

For seriously ill patients, it is advisable to increase the frequency of administration to 10 or more times. Duration of admission – 10 days.

The method of introducing microorganisms into the body is essential to achieve maximum therapeutic effect. Commercially available preparative forms allow the introduction of bacteria into the body: - orally, through the mouth (powders and capsules); — rectally (Enemas from liquid formulations provide maximum therapeutic effect when the drug is administered into the rectum to a depth of 10 cm).

To perform the procedure, you need to buy a urethral catheter No. 14, a medical syringe (at least 5 ml), 100 ml of saline solution in a container with a rubber stopper. Using a syringe, transfer the contents of a penicillin bottle (10 ml) with the drug into 100 ml of physiological solution. As a result, you will receive 110 ml of a ready-to-use working solution of the drug. Next, using a syringe with a capacity of at least 15 ml, take 10 ml of the working solution and additionally draw 3 ml of air, and instead of a needle, place a catheter pre-cut near the coupling. Lie on your right side. Bring your left leg closer to your chest and insert the catheter into the rectum to a depth of 10 cm. Place the syringe with liquid vertically and insert the contents into the rectum along with air. After administering the drug, you must lie on your right side for at least 15 minutes.); — when treating damaged areas of the skin, ointments containing the above microorganisms should be applied in a thin layer; the therapeutic effect depends on the frequency of treatment; — to normalize the composition of microbial communities on the skin surface, you should take baths with the addition of liquid formulations (10 ml of preparations based on the bacteria Bacillus subtilis strain VKPM B 7048 and Bacillus licheniformis strain VKPM B 7038, respectively, per bath); — to strengthen and stimulate hair growth, it is advisable to rinse it after washing with a solution of liquid formulations of preparations based on the bacteria Bacillus subtilis strain VKPM B 7048 and Bacillus licheniformis strain VKPM B 7038 (it is permissible to dilute them 10,000 times); This effect is ensured by the fact that the quality of the hair is directly dependent on the composition of the microbial community on the surface of the head - treatment with liquid preparations brings it into line with the environmentally natural one.

The only contraindication is individual intolerance to the active principle. It can be expressed as an allergy to Bacillus subtilis. This type of disease is extremely rare and can appear as a rash on the body. In this case, taking the medications must be stopped. The rash will go away in a few days. Preparations based on Bacillus subtilis strain VKPM B 7048 and Bacillus licheniformis strain VKPM B 7038 should be taken regularly: orally, applied to the skin (baths are allowed), mucous membranes, it should get into the eyes and nose.

What are the storage conditions for VETOmov and BIOSEPTIN?

Answer:

Where can I buy your drugs?

How to properly insert suppositories into the rectum

1. Wash your hands well. Wear thin medical gloves.
2. Read the instructions for using the suppositories, check whether the dosage is determined correctly. If you need to insert only half of the candle, divide it not across, but along.
3. The medicine can be administered lying down or standing. Preferably in the first position.
4. Lie down on your left side. Raise your left buttock, bend your right leg at the knee, and pull it towards your chest. Carefully insert a candle into the anus pre-lubricated with Vaseline.
5. Push the suppository slightly with your finger 2-2.5 cm deep.
6. Squeeze your buttocks and lie there for a few minutes.
7. If you insert the suppository while standing, spread the buttocks with one hand and insert the drug with the other.
8. Lie down and lie down - the medicine needs to dissolve and start working.

How to administer suppositories rectally to a child?

There are two options for administering a suppository to a small patient:

1. Hold the medicine with one hand and lift the child onto his heels with the other. Gently insert the suppository into the baby's anus. To do this, use your little finger and push the drug 1.5 cm deep. This method is suitable for very young children.
2. To treat older patients, the child is placed on the left side and the legs bent at the knees are brought to the chest. With one hand, spread the child's buttocks, with the other, insert the suppository.

In both cases, before carrying out the manipulations, wash your hands well, put on thin medical gloves, and lubricate the patient’s anus with Vaseline.

Attention! Make sure that the child lies down for 10-15 minutes - the candle will dissolve and begin to “work”. If you use suppositories for constipation, it is not necessary to wait this long.

Principles of using rectal suppositories in the treatment of constipation

Constipation is an extremely common condition. According to statistics, in economically developed countries, constipation affects 5 to 10% of the population (1).

Constipation is a chronic delay in bowel movement for more than 48 hours, accompanied by difficulty in defecation, a feeling of incomplete evacuation with the passage of a small amount (less than 100 g) and increased hardness of stool. The main function of the colon is to convert the liquid contents of the ileum into solid stool before it reaches the rectum and is eliminated. Several processes contribute to normal colon function

: absorption of liquid and electrolytes, peristaltic contractions that provide mixing, “squeezing out” moisture, moving feces to the rectum - and ends with defecation (2).

A.V. Frolkis (1979) identifies the following etiological types of constipation:

1. Alimentary constipation

– develops with improper and irrational nutrition, mechanically and chemically gentle food with limited plant fiber.

2. Neurogenic constipation

– occurs most often and occurs in connection with disturbances in the mechanisms of regulation of intestinal motility at any level of the nervous system. Neurogenic constipation is divided into

a) dyskinetic;

b) reflex;

c) due to suppression of the urge to defecate (habitual constipation).

Dyskinetic constipation is caused by primary intestinal dyskinesia (hypokinetic or spastic); reflex constipation develops with various diseases of the digestive system, genitourinary system and other organs (secondary intestinal dyskinesia). A weakening of the urge to defecate can occur as a result of primary psychogenic influences (habitual constipation caused by suppression of the urge to defecate in the absence of the opportunity to recover, with a feeling of false shame, during a long trip, when changing the usual environment, changing the rhythm of life, fear of pain with hemorrhoids, fissures anus, etc., reluctance to go to the toilet with the habit of lying in bed for a long time in the morning, with passion for games, the need to empty the bowels in an unusual position, in the presence of strangers in patients on strict bed rest, etc.). Constant suppression of the urge to defecate leads to dyschezia, a condition in which the threshold of sensitivity to distension of the rectal ampulla increases.

3. Hypodynamic constipation

– caused by low physical activity of a person, physical inactivity, and weakness of somatic muscles. Hypodynamic constipation can occur in patients who have been on bed rest for a long time, in pregnant women, as well as in the elderly due to a sharp decrease in activity.

4. Constipation due to inflammatory bowel disease

(irritable bowel syndrome) - observed in patients with chronic colitis, less often - chronic enteritis.

5. Proctogenic constipation

– observed in patients with diseases of the anorectal area (hemorrhoids, anal fissures, proctalgia, etc.).

6. Mechanical constipation

– develops in patients with intestinal tumors, with cicatricial narrowing of the colon, mechanical compression of the rectum from the outside, etc.

7. Constipation due to an abnormal development of the colon

– observed in persons with congenital megacolon, idiopathic megacolon, with a mobile cecum and sigmoid colon, in persons with constitutional splanchoptosis.

8. Toxic constipation

– observed in chronic occupational poisoning (lead, mercury, thallium), and nicotine poisoning in smokers.

9. Constipation due to disturbances in water-electrolyte metabolism

– develops with heart failure, renal failure, dehydration of any origin.

10. Endocrine constipation

– observed primarily in hypothyroidism (hypotonic type of constipation), hypoparathyroidism (hypertensive, spastic type of constipation), pituitary insufficiency, less often in diabetes mellitus, adrenal insufficiency, fuochrocytoma, glucagonoma, menopause.

11. Medical constipation

– caused by taking certain medications (3).

Constipation can be accompanied by a number of general phenomena: weakness, malaise, headaches, irritability, insomnia, decreased appetite, palpitations, sweating, vague abdominal pain. Constipation accelerates the aging process of the body (1).

Treatment of constipation must begin with identifying the cause, after a complete examination of the patient

.
First of all, it is advisable to empty the intestines of stagnant feces. For this purpose, laxatives are used to enhance intestinal motility and facilitate the passage of feces. Bisacodyl rectal suppositories
fully possess these properties . This laxative belongs to a group of drugs that stimulate intestinal function and help soften stool.

Pharmacological action of Bisacodyl

The active ingredient of the drug is bisacodyl or bis-(4-acetoxyphenyl)-(pyridyl-2)-methane (4). By breaking down in the alkaline contents of the intestine, bisacodyl has a laxative effect due to:

• direct effect on the smooth muscles of the colon due to the chemical effect on the intramural nerve plexuses, stimulating increased and accelerated intestinal motility;

• irritation of the receptors of the mucous membrane, due to which the production of mucus in the large intestine increases, feces soften and improve their sliding, which promotes the act of defecation.

Local use of suppositories allows, with minimal absorption of the drug, to achieve a rapid and pronounced laxative effect: after 15 minutes - 1 hour.

The type of stool formed when using Bisacodyl-Nizhpharm suppositories is close to physiological - soft or formed (5).

An important fact is that bisacodyl does not penetrate into the milk of a nursing woman (4).

Indications for use

The drug is effective for constipation caused by hypotension of the colon (in elderly patients, after surgery, childbirth). "Bisacodyl-Nizhpharm" reduces the need for regular use of enemas in elderly and senile people. The use of the drug is indicated for regulating stool for hemorrhoids, proctitis, anal fissures, preparation for surgical operations, instrumental and x-ray examinations.

Directions for use and doses

Having freed the suppository from the contour packaging using scissors (cutting the packaging along the contour of the suppository), Bisacodyl is administered into the rectum in the following doses:

• adults 1–2 suppositories per day;

• at the age of 15–18 years, 1–2 suppositories per day;

• at the age of 8–14 years – 1 suppository per day;

• children aged 1–7 years, 1/2 suppository per day - as prescribed by a doctor.

If a drug is prescribed to cleanse the intestines in preparation for surgery or an x-ray examination of the abdominal organs, one suppository is administered in the morning (4).

Before insertion into the rectum, suppositories should be moistened with water, held under running water for 30 s or placed in a cup of water for at least 10 s (5).

Side effects and contraindications

Usually the drug is well tolerated.

Contraindications for use are intestinal obstruction of various etiologies, acute inflammatory diseases of the abdominal organs, undiagnosed rectal bleeding, acute hemorrhoids, acute proctitis, spastic constipation.
Literature
1. Brief medical encyclopedia: In 2 volumes, ed. acad. RAMS V.I. Pokrovsky, M. NPO “Medical Encyclopedia”, “Kron-press”, 1994; T. 1. Mechanotherapy, 371.

2. Grigoriev P.Ya., Yakovenko A.V. Clinical gastroenterology. textbook for medical students, M. M.: medical information agency. 1998; 464.

3. Mashkovsky M.D. Medicines. In 2 volumes, 13th ed. Kharkiv. Torsing, 1997; 2:339.

4. Information about medicines for healthcare professionals / Ed. acad. RAMS M.D. Mashkovsky:

Vol. 4. Medicines used in gastroenterology. M. RC “Pharmedinfo”, 1998; 122.

5. Okorokov A.N. Treatment of internal organs: Practical guide: In 3 volumes. Mn.: Higher. school, Belmedkniga, 1995.

vol. 1, p. 378.

Bisacodyl –

Bisacodyl (trade name)

(Nizhpharm)

How to measure temperature rectally

It may be necessary to measure rectal temperature in case of thermoneurosis, illnesses in young children, hypothermia of the patient's body, or in an unconscious state of the patient.

You will need to use an electronic or mercury thermometer:

1. Wash your hands.
2. Lie on your side, pre-treat the thermometer with a disinfectant and rinse with running water.
3. Lubricate the tip of the thermometer with Vaseline.
4. Carefully insert the thermometer into the anus to a depth of 5 cm, tighten your buttocks.
5. Wait 5 minutes. If you are using an electronic device, it will beep.

Attention! Human internal organs have a higher temperature, so the normal rectal temperature can be up to 37.7 degrees.

An alternative to suppositories - enemas

In some cases, doctors recommend that patients be treated not with anti-inflammatory rectal suppositories, but with classic enemas. If the enema is large (more than 1 liter), you will need to use an Esmarch mug.

The algorithm of actions is simple:

1. Fill the container with the required amount of medicinal solution.
2. Hang the mug on a tripod so that it is higher than your body (at least 1 m).
3. Lubricate the tip of the tube with Vaseline and carefully insert it into the anus a few centimeters.
4. Serve the liquid in small portions.
5. Lie down for a while.
6. As soon as you feel the urge, empty your bowels.

When using microenemas, simply insert the tip into the anus to the mark and press on the capsule.