The role and place of Mexidol in the treatment of metabolic syndrome

General information about Mildronate

Mildronate is used in the treatment of various diseases to improve intracellular metabolism, to increase vitality and has a general strengthening effect. The active ingredient is meldonium.

Due to its cardioprotective properties, it is used in the treatment of heart diseases associated with ischemia (reduces necrotic zones during myocardial infarction, reduces the frequency and duration of angina attacks).

Effects of the drug Mildronate on the body

The drug is able to improve blood supply to the brain, which leads to improved cognitive functions, increased performance, and shortens the recovery period after strokes. It fights hypoxia at the cellular level - this allows it to be used in sports to restore the strength of athletes between performances and during training.

This drug is produced by a Latvian pharmacological company in various forms for ease of use:

• capsules;
• syrup;
• solution for injection (intramuscular, intravenous and parabulbar).

Mildronate has a preventive effect on the course of the disease, improving the course of the disease, alleviating the patient's condition, but in the acute period it may not have the desired effect. It has a beneficial effect on the emotional background, reduces the impact of stress factors on the body, reduces anxiety, and improves sleep.

Reviews

Evgeniya, cardiologist, 47 years old, Irkutsk, prescribes Mexidol for pathologies associated with vascular ischemia and as therapy to prevent the development of pre-infarction conditions. The course of treatment is combined with a drug such as Mildronate. Together, medications can achieve good results.

Maxim, neurologist, 52 years old, Moscow For patients who have symptoms of neuralgia and frequent seizures, I recommend the use of Mildronate. The greatest therapeutic effect is achieved when taking Mexidol.

Nikolai, 58 years old, Bratsk began to see worse and noticed that his eyes often hurt, as if something were pressing on them, in addition, the condition was accompanied by the flickering of spots. I decided to see an ophthalmologist, who prescribed me Mexidol. But after it I started having small rashes, which became very annoying. The doctor replaced the drug with Mildronate. Now I feel better, the rash is gone.

Svetlana, 46 years old, Kursk

As prescribed by the doctor, I used intramuscular injections of Mexidol for VSD. During administration, slight pain and burning are felt, which quickly pass. Otherwise the medicine is well tolerated. The course of treatment allows you to eliminate the symptoms of the disease and improve your general condition. Weakness decreases, the headache stops hurting, the feeling of anxiety goes away. Among the advantages of the product, I would like to note its low cost.

Galina, 47 years old, Shakhtinsk

I get very physically tired at work. I learned from an advertisement that Mildronate helps with such conditions. The price of the medicine is low, so I decided to buy it and try treatment. The pills have an effect. The body's tone and efficiency increase, and vigor appears. It became easier to bear the load.

Vika, 31 years old, Moscow

My mother has cerebral atherosclerosis. She regularly takes Mexidol. It improves blood microcirculation and eliminates the symptoms of the disease. The headaches go away and my heart worries less. The product has a positive effect on the nervous system, calms it, relieves tension and anxiety. Cramps decrease, blood pressure normalizes.

Today, the pharmaceutical industry presents numerous drugs that can improve metabolic processes at the cellular level.

What is better Mexidol or Mildronate in each specific case will be determined by the attending physician, instructions for use, as well as studying additional information about the drugs.

Elena, 34 years old, Kyiv My father has a strong craving for alcohol. He usually drinks for about two weeks, and it’s hard to break out of the binge. His heart begins to ache, his hands shake, convulsions appear, feelings of anxiety, fear, a depressive state gives way to aggression, and sleep is disturbed. Encodings don't help. It becomes scary for his health.

Igor, 44 years old, Moscow, university teacher Lately he has become very unbalanced. At work I lashed out at students and colleagues, my wife and children constantly irritated me, and I developed a feeling of fear. Because of his character, he was constantly in conflict with someone. Friends advised me to drink Mildronate.

I started taking one capsule in the morning and evening. It was possible to fall asleep only in the morning, almost before getting up. The condition only worsened. I had to see a doctor. As it turned out, Mildronate should not be taken immediately before bedtime. The specialist advised me to undergo a course of treatment with Mexidol. The drug really helped me. Now the neurotic manifestations have disappeared. Thanks Mexidol.

Irina Vasilievna, 60 years old, pensioner Several years ago I began to feel unpleasant symptoms: strong heartbeat, alternating with interruptions, shortness of breath, chest pain on the left side. The doctor diagnosed coronary heart disease and prescribed Mildronate. The medicine is quite expensive, but completely worth it.

Mexidol is a fairly common drug. It is prescribed to patients who experience discomfort from diseases associated with cerebral circulation. There is another similar drug called Mildronate. A question that a person may have is whether Mexidol and Mildronate can be used together?

General information about Mexidol

The main effect of Mexidol is to reduce tissue hypoxia by improving the ability of tissues to absorb oxygen supplied by the blood. Due to this, the cognitive functions of the brain are improved, seizures of various etiologies are stopped, anxiety and stress on the body are reduced.

Thanks to its antioxidant properties, this drug slightly improves immunity. Mexidol has a strong effect on higher nervous functions. When taken, attention, thinking, and the ability to remember increase, emotional reactions are normalized, anxiety and fear are reduced, and sleep is normalized. This allows it to be widely used in neurology.

Mexidol is produced by several domestic manufacturers; it is based on a substance - ethylmethylhydroxypyridine succinate. It has various forms of release:

• pills;
• solution for injection (intramuscular, intravenous).

Alcohol compatibility

Although the drugs have similar effects, their interaction enhances the therapeutic effect of the treatment.

Specialists can combine drugs:

• for brain pathologies;
• ischemic stroke (together with Actovegin);
• cerebral ischemia, as well as vestibulo-atactic syndrome (appearance of spots before the eyes, nausea, dizziness, etc.);
• abnormal heart rhythm;
• non-inflammatory damage to the heart muscle;
• withdrawal syndrome.

It is impossible to give an exact answer: which is better, Mildronate or Mexidol. Each drug is designed to get rid of certain diseases and the advisability of their use depends on the choice of the doctor.

The drugs are prescribed simultaneously for the following indications:

• cardiac conduction disorders
• withdrawal syndrome
• complex treatment of ischemic pathologies of the brain (stroke, vascular dysfunction).

The combined use of medications helps to recover from:

• chronic alcoholism
• suffered ischemic stroke
• psychoorganic syndrome (behavioral disorder, decreased intelligence)

The drugs are widely used to treat people who drink excessive amounts of alcohol. They help eliminate toxic substances and reduce their impact on the body.

The principle of action of the drugs

Mexidol's main effect in the human body is on the cell membrane. This drug has a membrane-protective effect, which affects lipid peroxidation of the cell wall. At the same time, the viscosity of the cell membrane decreases and its fluidity increases, the cell becomes more resistant to external influences.

The binding capacity of membrane receptors also increases, synaptic transmission and transport of neurotransmitters improves. Thanks to these effects, the nootropic effect of the drug is manifested (memory, speech, thinking improves).

The antihypoxic effect of Mexidol in cardiomyocytes manifests itself in the form of a decrease in the area of ​​necrosis and ischemia during myocardial infarction, and an improvement in the contractility of cardiac muscle tissue. The damaging effects of hypoxia and other unfavorable factors on the human body are reduced.

Once in the body, Mildronate blocks the enzyme carnitine, while having a vasodilating effect on blood vessels, reducing platelet aggregation, and reducing the content of toxic products of anaerobic glycolysis in cells. This leads to the restoration of the relationship between the cell's need for oxygen and its supply with the blood.

Evaluation of the effectiveness and safety of Mildronate

Thus, tissues are saturated with oxygen-rich blood, and glycolysis in cells becomes more efficient. Tolerance to physical activity increases. Complex therapy for myocardial infarction, including the use of Mildronate, reduces the area of ​​necrosis, which allows patients to recover faster and reduce the rehabilitation period.

Indications and contraindications

Both drugs are used for various pathologies and conditions. Mildronate is prescribed for:

1. IHD and CHF.
2. Pre-infarction and myocardial infarction.
3. CVB (cerebral crises in which oxygen enters the brain in insufficient quantities).
4. Dyshormonal cardiomyopathy.

Mexidol is used for:

1. Chronic cerebral circulatory failure.
2. Damages of cerebral vessels.
3. VSD.
4. Atherosclerosis.
5. Tissue hypoxia.

Mildronate is strictly contraindicated during pregnancy and breastfeeding, children under 18 years of age and patients suffering from increased intracranial pressure, as well as individual intolerance to the constituent components.

In case of severe liver or kidney diseases, it can be used only after an examination. In patients with crisis hypertension or hypotension, use is possible, but examination and medical supervision is necessary.

Overdose

Both drugs must be consumed in accordance with the prescribed dosage. When taking too large a dose of Mexidol, the patient most often develops drowsiness. Mildronate is characterized by low toxicity and does not cause reactions that could affect the health of patients. Treatment of overdose should be symptomatic. Exceeding the recommended dose of Mildronate in a person can be determined by the following symptoms:

• decreased blood pressure along with headache;
• dizziness;
• tachycardia;
• general weakness of the body.

In case of overdose, it is necessary to call the patient an ambulance as quickly as possible. While she is driving, you can try to give him first aid. It should consist of gastric lavage.

Instructions for use

For coronary heart disease, Mexidol is used for 1-1.5 months, and this course is repeated 2 times a year, mainly in spring and autumn. Treatment begins with 1-2 tablets (125-250 mg) and titrates until the effect is achieved. The maximum dose can be 800 mg - 6 tablets.

The course of treatment with meldonium drugs is usually long, from several weeks to several months. The daily dose for heart disease is 500-1000 mg, divided into 2 doses. For cardialgia associated with cardiomyopathy, the therapeutic effect is achieved with a dose of 500 mg once a day.

In the acute period of stroke, Mildronate can be prescribed first in the form of intravenous injections and after 2 weeks in the form of tablets for 2 months. In the treatment of chronic alcohol intoxication, a 1-2 week course of taking the drug at a dose of 500 mg 4 times a day is used.

It is important not to exceed the established maximum permissible dose of 2 g, as it is possible to develop undesirable side effects in the form of excessive excitability of the nervous system.

Since the drugs are similar in their action, many are concerned about the question of whether it is possible to take these drugs at the same time. Since the mechanism of action of these drugs is different, when used together, a summation of effects is observed. The dose of drugs when taken together is calculated in the same way as separately. That is, 500 mg of each product.

Main differences

The main difference between Mildronate and Mexidol is their composition, which determines the properties of the medications, and thanks to which you can understand the difference between them. The first drug contains Meldonium, the second one contains ethylmethylhydroxypyridine succinate.

When taking Mildronate, a number of important effects are observed:

• 
  blood supply to organs with oxygen-rich blood improves;

• myocardial contractility increases, while the frequency and strength of angina attacks decreases;
• tolerance to physical activity increases by reducing oxygen starvation of tissues;
• improves heart function and blood supply to cardiomyocytes by reducing ischemia.

Mexidol increases the body's resistance to adverse factors (ischemia, hypoxia, chemical intoxication), has a membrane-protective effect, improves the rheological properties of blood, and relieves withdrawal symptoms caused by prolonged alcohol consumption. Effective for nervous tics and increased emotional stress, improves cognitive functions of the brain.

Analogs

The most effective drugs with a similar effect as Mildronate are:

• Angiocardil;
• Vazonat;
• Energoton;
• Idrinol;
• Cardazin;
• Cardionate;
• Carduktal;
• Meldonium;
• Melfort;
• Metazidine;
• Mildrocard;
• Mildroxin;
• Presidin;
• Riboxin;
• Triductan, etc.

The highest quality analogues of Mexidol:

• Actovegin;
• Neurox;
• Mexicofin;
• Mexico;
• Mexiprim;
• Astrox;
• Cerecard, etc.